Pharmaceutical
FDA Approved Medications For Hair Regrowth
These Medications have been approved because of their ability to assist with hair regrowth in both men and women who are suffering from different types of hair loss.
Finasteride or Propecia®
Propecia® is a prescription medicine used for the treatment of male pattern hair loss (androgenetic alopecia). It is not known if Propecia® works for a receding hairline on either side of and above your forehead (temporal area).
Is for use by MEN ONLY and should NOT be used by women or children.
Who should not take Propecia®? Do not take Propecia® if you:
• are pregnant or may become pregnant. Propecia® may harm your unborn baby. Propecia® tablets are coated and will prevent contact with the medicine during handling, as long as the tablets are not broken or crushed. Females who are pregnant or who may become pregnant should not come in contact with broken or crushed Propecia® tablets. If a pregnant woman comes in contact with crushed or broken Propecia® tablets, wash the contact area right away with soap and water. If a woman who is pregnant comes into contact with the active ingredient in Propecia®, a healthcare provider should be consulted.
If a woman who is pregnant with a male baby swallows or comes in contact with the medicine in Propecia®, the male baby may be born with sex organs that are not normal.
• are allergic to any of the ingredients in Propecia®. See the end of this leaflet for a complete list of ingredients in Propecia®.
What should I tell my healthcare provider before taking Propecia®?
Before taking Propecia®, tell your healthcare provider if you:
• have any other medical conditions, including problems with your prostate or liver
Tell your healthcare provider about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Know the medicines you take. Keep a list of them to show your healthcare provider and pharmacist when you get a new medicine.
How should I take Propecia®?
• Take Propecia® exactly as your healthcare provider tells you to take it.
• You may take Propecia® with or without food.
• If you forget to take Propecia® do not take an extra tablet. Just take the next tablet as usual.
Propecia® will not work faster or better if you take it more than once a day.
What are the possible side effects of Propecia®?
• Decrease in your blood Prostate Specific Antigen (PSA) levels. Propecia® can affect a blood test called PSA (Prostate-Specific Antigen) for the screening of prostate cancer. If you have a PSA test done you should tell your healthcare provider that you are taking Propecia® Propecia® decreases PSA levels. Changes in PSA levels will need to be evaluated by your healthcare provider. Any increase in follow-up PSA levels from their lowest point may signal the presence of prostate cancer and should be evaluated, even if the test results are still within the normal range for men not taking Propecia®. You should also tell your healthcare provider if you have not been taking Propecia® as prescribed because this may affect the PSA test results. For more information, talk to your healthcare provider.
• There may be an increased risk of a more serious form of prostate cancer in men taking finasteride at 5 times the dose of Propecia®.
The most common side effects of Propecia® include:
• decrease in sex drive
• trouble getting or keeping an erection
• a decrease in the amount of semen
The following have been reported in general use with Propecia®:
• breast tenderness and enlargement. Tell your healthcare provider about any changes in your breasts such as lumps, pain or nipple discharge.
• depression;
• decrease in sex drive that continued after stopping the medication;
• allergic reactions including rash, itching, hives and swelling of the lips, tongue, throat, and face;
• problems with ejaculation that continued after stopping medication;
• testicular pain;
• difficulty in achieving an erection that continued after stopping the medication;
• male infertility and/or poor quality of semen.
• in rare cases, male breast cancer.
Tell your healthcare provider if you have any side effect that bothers you or that does not go away.
These are not all the possible side effects of Propecia®. For more information, ask your healthcare provider or pharmacist.
Call your doctor for medical advice about side effects.
How should I store Propecia®?
• Store Propecia® at room temperature between 59˚F to 86˚F (15˚C to 30˚C).
• Keep Propecia® in a closed container and keep Propecia® tablets dry (protect from moisture).
General information about the safe and effective use of Propecia®
Medicines are sometimes prescribed for purposes other than those listed in this Patient Information leaflet. Do not use Propecia® for a condition for which it was not prescribed. Do not give Propecia® to other people, even if they have the same symptoms you have. It may harm them.
What are the ingredients in Propecia®?
Active ingredient: finasteride.
Inactive ingredients: lactose monohydrate, microcrystalline cellulose, pregelatinized starch, sodium starch glycolate, hydroxypropyl methylcellulose, hydroxypropyl cellulose, titanium dioxide, magnesium stearate, talc, docusate sodium, yellow ferric oxide, and red ferric oxide.
This Patient Information has been approved by the U.S. Food and Drug Administration.
Minoxidil
Minoxidil is one of the active ingredients used in the specially compounded topical solution for hair regrowth at The Hair Clinic. Minoxidil is an antihypertensive vasodilator medication and is used to treat hair loss. It is available as a generic medication and over the counter for the treatment of androgenic alopecia, a form of hair loss, in men and women.
Medical Uses
Minoxidil, applied topically, is widely used for the treatment of hair loss. It is effective in helping promote hair growth in both men and women with androgenic alopecia.[5] About 40% of men experience hair regrowth after 3–6 months.[6] Minoxidil must be used indefinitely for continued support of existing hair follicles and the maintenance of any experienced hair regrowth.[4]. Its effect in people with alopecia areata is unclear.
Adverse Effects
Minoxidil is generally well tolerated, but common side effects include burning or irritation of the eye, itching, redness or irritation at the treated area, and unwanted hair growth elsewhere on the body. Exacerbation of hair loss/alopecia has been reported.[8][9] Severe allergic reactions may include rash, hives, itching, difficulty breathing, tightness in the chest, swelling of the mouth, face, lips, or tongue, chest pain, dizziness, fainting, tachycardia, headache, sudden and unexplained weight gain, or swelling of the hands and feet.[10] Temporary hair loss is a common side effect of minoxidil treatment.[11] Manufacturers note that minoxidil-induced hair loss is a common side effect and describe the process as "shedding".
Alcohol and propylene glycol present in some topical preparations may dry the scalp, resulting in dandruff and contact dermatitis.[12]Side effects of oral minoxidil may include swelling of the face and extremities, rapid and irregular heartbeat, light headedness, cardiac lesions, and focal necrosis of the papillary muscle and subendocardial areas of the left ventricle.[9] Cases of allergic reactions to minoxidil or the non-active ingredient propylene glycol, which is found in some topical minoxidil formulations, have been reported. Pseudoacromegaly is an extremely rare side effect reported with large doses of oral minoxidil.[13]Minoxidil may cause hirsutism, although is is exceedingly rare and reversible by discontinuation of the drug.
Mechanism Of Action
The mechanism by which minoxidil promotes hair growth is not fully understood. Minoxidil is a potassium channel opener,[15] causing hyperpolarization of cell membranes. Hypothetically, by widening blood vessels and opening potassium channels, it allows more oxygen, blood, and nutrients to the follicles. This may cause follicles in the telogen phase to shed, which are then replaced by thicker hairs in a new anagen phase. Minoxidil is a prodrug that is converted by sulfation via the sulfotransferase enzyme SULT1A1 to its active form, minoxidil sulfate. Several studies demonstrated that the activity of sulfotransferase in hair follicles predict minoxidil response in the treatment of hair loss.[16][17][18]
